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Article

Duplication of Philadelphia chromosome and trisomy of chromosome 21 in a pediatric patient with acute lymphoblastic leukemia.

Medical oncology (Northwood, London, England) - 1 Dec 2011

Katsibardi Katerina, Braoudaki Maria, Papadhimitriou Stefanos I, Karamolegou Kalliopi, Tzortzatou-Stathopoulou Fotini

Abstract excerpt

The evaluation of molecular and cytogenetic characteristics using novel techniques has significantly contributed into the insight of leukemia. In this study, immunoglobulin heavy chain gene rearrangements (V(H)D(H)J(H) region) were analyzed by polymerase chain reaction (PCR). Point mutations of the D835/I836 in the activation loop (AL) domain of the second tyrosine kinase domain of the fms-related tyrosine kinase...

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Source

Identifiers

PMID: 20924716
DOI: 10.1007/s12032-010-9689-7

Genes

FLT3
ABL1
BCR
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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