Article
Additional chromosomal abnormalities and variability of BCR breakpoints in Philadelphia chromosome/BCR-ABL-positive acute lymphoblastic leukemia in Taiwan.
American journal of hematology - 1 Dec 2002
Ko Bor-Sheng, Tang Jih-Lu, Lee Fen-Yu, Liu Ming-Chi, Tsai Woei, Chen Yao-Chang, Wang Chiu-Hwa, Sheng Ming-Chin, Lin Dong-Tsam, Lin Kai-Hsin, Tien Hwei-Fang
Abstract excerpt
From 1986 to 1998, 26 (23%) of 114 adult acute lymphoblastic leukemia (ALL) patients and 11 (4%) of 328 pediatric patients were found to have Philadelphia (Ph) chromosome. In the 30 patients with available data at diagnosis, 18 (60%) had extra-chromosomal abnormalities. They included 1q duplication (5/18, 28%), supernumerary Ph chromosome (4/18, 22%), 9p abnormalities (3/18, 17%), 7q deletion/monosomy 7 (3/18,...
Topics
- Actins
- Adolescent
- Adult
- Chromosome Aberrations
- DNA Primers
- Female
- Fusion Proteins, bcr-abl
- Genes, abl
- Genetic Variation
- Humans
- In Situ Hybridization, Fluorescence
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive