Article
Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing.
Genetics - 1 Dec 2010
Birkeland Shanda R, Jin Natsuko, Ozdemir Alev Cagla, Lyons Robert H, Weisman Lois S, Wilson Thomas E
Abstract excerpt
Many novel and important mutations arise in model organisms and human patients that can be difficult or impossible to identify using standard genetic approaches, especially for complex traits. Working with a previously uncharacterized dominant Saccharomyces cerevisiae mutant with impaired vacuole...
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