Article
Evaluation of the influence of polymorphic variants CYP1A1 2B, CYP1B1 2, CYP3A4 1B, GSTM1 0, and GSTT1 0 in prostate cancer.
Urologic oncology - 1 Jan 2000
Rodrigues Iara S, Kuasne Hellen, Losi-Guembarovski Roberta, Fuganti Paulo E, Gregório Emerson P, Kishima Marina O, Ito Kazuhiro, de Freitas Rodrigues Marco A, de Syllos Cólus Ilce M
Abstract excerpt
BACKGROUND/OBJECTIVE: Genetic polymorphisms in cytochrome P-450 (CYPs) and glutathione S-transferase (GSTs) genes can influence the appearance of tumors by the formation of new enzymes with altered activities. In the present study, 5 polymorphic variants were examined in 154 patients with prostate carcinoma and in 154 controls. MATERIALS AND METHODS: DNA analysis was carried out through PCR-based methods. The...
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