Article
Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients.
The Journal of antimicrobial chemotherapy - 1 Dec 2010
Siikala Emilia, Rautemaa Riina, Richardson Malcolm, Saxen Harri, Bowyer Paul, Sanglard Dominique
Abstract excerpt
OBJECTIVES: Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I) suffer from chronic candidosis caused mainly by Candida albicans, and repeated courses of azole antifungals have led to the development of resistance in the APECED patient population in Finland. The aim of our study was to address whether the patients are persistently colonized with the same or genetically...
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