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Article

Low CD10 mRNA expression identifies high-risk ductal carcinoma in situ (DCIS).

PloS one - 10 Aug 2010

Toussaint Jérôme, Durbecq Virginie, Altintas Sevilay, Doriath Valérie, Rouas Ghizlane, Paesmans Marianne, Bedard Philippe, Haibe-Kains Benjamin, Tjalma Wiebren A, Larsimont Denis, Piccart Martine, Sotiriou Christos

Abstract excerpt

PURPOSE: Optimal management of breast ductal carcinoma in situ (DCIS) is controversial, and many patients are still overtreated. The local death of myoepithelial cells (MECs) is believed to be a pre-requisite to tumor invasion. We thus hypothesized that loss of CD10 expression, a MEC surface peptidase, would signify basement membrane disruption and confer increased risk of relapse in DCIS. The aim of our study...

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Identifiers

PMID: 20856894
DOI: 10.1371/journal.pone.0012100
PMCID: PMC2938371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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