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Article

Structure and immunomodulatory property relationship in NapA of Borrelia burgdorferi.

Biochimica et biophysica acta - 1 Dec 2010

Codolo Gaia, Papinutto Elena, Polenghi Alessandra, D'Elios Mario Milco, Zanotti Giuseppe, de Bernard Marina

Abstract excerpt

NapA from Borrelia burgdorferi is a member of the Dps-like protein family with specific immunomodulatory properties; in particular, NapA is able to induce the expression of IL-23 in neutrophils and monocytes, as well as the expression of IL-6, IL-1β, and transforming growth factor beta (TGF-β) in monocytes, via Toll-like receptor (TLR) 2. Such an activity on innate immune cells triggers a synovial fluid Th17...

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Source

Identifiers

PMID: 20851780
DOI: 10.1016/j.bbapap.2010.09.004

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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