Article
Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3.
Brain research - 18 Nov 2010
Yamamoto-Watanabe Yukiko, Watanabe Mitsunori, Jackson Mandy, Akimoto Hiroyuki, Sugimoto Kazuhiro, Yasujima Minoru, Wakasaya Yasuhito, Matsubara Etsuro, Kawarabayashi Takeshi, Harigaya Yasuo, Lyndon Alastair R, Shoji Mikio
Abstract excerpt
Cystatin C (CC) is a cysteine protease inhibitor abundantly expressed in the central nervous system. Bunina bodies, small eosinophilic intraneuronal inclusions, are stain positive for CC and are the most specific histological hallmark of amyotrophic lateral sclerosis (ALS). In this study, employing a latex turbidimetric immunoassay, levels of CC in cerebrospinal fluid (CSF) were quantified in 130 age-matched...
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