[Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].

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[Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 Jul 2010

Y U Min, Guo Xiong, Gao Xiao-Yun, Lai Jiang-Hua, Tu Qian-Qian

Abstract excerpt

OBJECTIVE: To investigate the association between IL-1beta and DVWA gene and Kashin-Beck disease (KBD). METHODS: Peripheral genomic DNA were extracted from 105 patients with KBD and 98 healthy controls. PCR-RFLP were performed to detect SNP loci of IL-1beta gene and DVWA gene. RESULTS: The patients with KBD had significantly higher frequency of rs16944 (IL-1beta) locus (chi2 = 24.28, P < 0.001) and single allele...

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PMID: 20848793

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