Article
Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly.
The Journal of biological chemistry - 31 Dec 2010
LeBleu Valerie, Sund Malin, Sugimoto Hikaru, Birrane Gabriel, Kanasaki Keizo, Finan Elizabeth, Miller Caroline A, Gattone Vincent H, McLaughlin Heather, Shield Charles F, Kalluri Raghu
Abstract excerpt
The network organization of type IV collagen consisting of α3, α4, and α5 chains in the glomerular basement membrane (GBM) is speculated to involve interactions of the triple helical and NC1 domain of individual α-chains, but in vivo evidence is lacking. To specifically address the contribution of the NC1 domain in the GBM collagen network organization, we generated a mouse with specific loss of α3NC1 domain...
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