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Article

Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients.

Molecular medicine (Cambridge, Mass.) - 1 Jan 2000

Pasmant Eric, Masliah-Planchon Julien, Lévy Pascale, Laurendeau Ingrid, Ortonne Nicolas, Parfait Béatrice, Valeyrie-Allanore Laurence, Leroy Karen, Wolkenstein Pierre, Vidaud Michel, Vidaud Dominique, Bièche Ivan

Abstract excerpt

Patients with NF1 microdeletion develop more neurofibromas at a younger age, and have an increased risk of malignant peripheral nerve sheath tumors (MPNSTs). We postulated that the increased risk of malignancy could be due to inactivation, in addition to NF1, of a second tumor suppressor gene located in the typical 1.4-Mb microdeletion found in most of the microdeleted patients. We investigated the expression of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20844836
DOI: 10.2119/molmed.2010.00079
PMCID: PMC3022985

Genes

ATAD5
OMG
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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