Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells.

Journal of cardiovascular translational research - 1 Dec 2010

Chiriac Anca, Terzic Andre, Park Sungjo, Ikeda Yasuhiro, Faustino Randolph, Nelson Timothy J

Abstract excerpt

Transformation of pluripotent stem cells into cardiac tissue is the hallmark of cardiogenesis, yet pro-cardiogenic signals remain partially understood. Preceding cardiogenic induction, a surge in CXCR4 chemokine receptor expression in the early stages of stem cell lineage specification coincides with the acquisition of pre-cardiac profiles. Accordingly, CXCR4 selection, in conjunction with mesoderm-specific VEGF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Share to Pluripotent Stem Cells

Share to Receptors, CXCR4

Share to RNA Interference

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 20842469
DOI: 10.1007/s12265-010-9219-1
PMCID: PMC3771645

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells.PMID 20842469Read ↗

Natural Cardiogenesis-Based Template Predicts Cardiogenic Potential of Induced Pluripotent Stem Cell LinesSemantic proximity Read ↗

Combined Lineage Tracing and scRNA-seq Reveals Unexpected First Heart Field Predominance of Human iPSC DifferentiationSemantic proximity Read ↗

Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiationSemantic proximity Read ↗

The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitorsSemantic proximity Read ↗

Forward programming of pluripotent stem cells towards distinct cardiovascular cell types.Semantic proximity Read ↗

Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4Semantic proximity Read ↗

Isolation and characterization of human embryonic stem cell-derived heart field-specific cardiomyocytes unravels new insights into their transcriptional and electrophysiological profilesSemantic proximity Read ↗

Deciphering transcriptional networks during human cardiac developmentSemantic proximity Read ↗

Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4Semantic proximity Read ↗

Cutting Edge: CXCR4-Lo: Molecular Cloning and Functional Expression of a Novel Human CXCR4 Splice VariantSemantic proximity Read ↗

Identification and characterization of hPSC-derived FOXA2+ progenitor cells with ventricular cardiac differentiation potentialSemantic proximity Read ↗

ErbB4 Activated p38γ MAPK Isoform Mediates Early Cardiogenesis Through NKx2.5 in Human Pluripotent Stem CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.