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Article

Relationships of circulating sex hormone-binding globulin with metabolic traits in humans.

Diabetes - 1 Dec 2010

Peter Andreas, Kantartzis Konstantinos, Machann Jürgen, Schick Fritz, Staiger Harald, Machicao Fausto, Schleicher Erwin, Fritsche Andreas, Häring Hans-Ulrich, Stefan Norbert

Abstract excerpt

OBJECTIVE: Recent data suggested that sex hormone-binding globulin (SHBG) levels decrease when fat accumulates in the liver and that circulating SHBG may be causally involved in the pathogenesis of type 2 diabetes in humans. In the present study, we investigated mechanisms by which high SHBG may prevent development to diabetes. RESEARCH DESIGN AND METHODS: Before and during a 9-month lifestyle intervention, total...

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Identifiers

PMID: 20841609
DOI: 10.2337/db10-0179
PMCID: PMC2992779

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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