Article
Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Jan 2010
Hayashi Hideki, Horino Masato, Morishita Mariko, Tazoe Yui, Tsuboi Seiji, Matsuyama Taiji, Kosuge Kazuhiro, Yamada Hiroshi, Tsuji Daiki, Inoue Kazuyuki, Itoh Kunihiko
Abstract excerpt
Dihydrofolate reductase gene (DHFR) 19-bp deletion polymorphisms result in varied DHFR enzymatic activity affecting the risk for preterm delivery, spina bifida, and the efficacy of methotrexate (MTX). Ethnic differences in DHFR 19-bp polymorphisms may be responsible for the divergent findings in previous genetic studies. We compared genotype and allele frequency of DHFR intronic 19-bp deletion polymorphisms in...
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