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Article

A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users.

The American journal of clinical nutrition - 1 Apr 2007

Xu Xinran, Gammon Marilie D, Wetmur James G, Rao Manlong, Gaudet Mia M, Teitelbaum Susan L, Britton Julie A, Neugut Alfred I, Santella Regina M, Chen Jia

Abstract excerpt

BACKGROUND: Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) into tetrahydrofolate (THF) and plays an essential role in cell metabolism and cellular growth. Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions. OBJECTIVES: We examined the relation of a 19-base pair (bp) deletion polymorphism of the DHFR gene with the risk of breast cancer by using data...

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Identifiers

PMID: 17413111
DOI: 10.1093/ajcn/85.4.1098

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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