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Article

Transcription factor HAND2 mutations in sporadic Chinese patients with congenital heart disease.

Chinese medical journal - 1 Jul 2010

Shen Lei, Li Xiao-Feng, Shen A-Dong, Wang Qiang, Liu Cai-Xia, Guo Ya-Jie, Song Zhen-Jiang, Li Zhong-Zhi

Abstract excerpt

BACKGROUND: The basic helix-loop-helix transcription factor HAND2 plays an essential role in cardiac morphogenesis. However, the prevalence of HAND2 mutations in congenial heart disease (CHD) and the correlation between the HAND2 genotype and CHD phenotype have not been studied extensively. METHODS: We amplified the exons and the flanking intron sequences of the HAND2 gene in 131 patients diagnosed with...

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Source

Identifiers

PMID: 20819618

Genes

HAND2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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