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Article

Functional analysis of HECA variants identified in congenital heart disease in the Chinese population.

Journal of clinical laboratory analysis - 1 Sept 2022

Li Ting, Wu Yao, Chen Wei-Cheng, Xue Xing, Suo Mei-Jiao, Li Ping, Sheng Wei, Huang Guo-Ying

Abstract excerpt

BACKGROUND: Congenital heart disease (CHD) is a class of cardiovascular defects that includes septal defects, outflow tract abnormalities, and valve defects. Human homolog of Drosophila headcase (HECA) is a novel cell cycle regulator whose role in CHD has not been elucidated. This is the first study to determine the frequency of HECA mutations in patients with CHD and the association between HECA variants and...

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Identifiers

PMID: 35949005
DOI: 10.1002/jcla.24649
PMCID: PMC9459261

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