Article
Lack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred mice.
Comparative medicine - 1 Aug 2010
Ding Ming, Arnold Jennifer, Turner Jeremy, Ramkumar Vickram, Hughes Larry F, Trammell Rita A, Toth Linda A
Abstract excerpt
The nucleotide substitution C797T in the Chrm2 gene causes substitution of leucine for proline at position 266 (P266L) of the CHRM2 protein. Because Chrm2 codes for the type 2 muscarinic receptor, this mutation could influence physiologic and behavioral phenotypes of mice. Chrm2 mRNA was not differentially expressed in 2 brain regions with high cholinergic innervation in a mouse strain that does (BALB/cByJ) or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.