Article
Role of surface protein SasG in biofilm formation by Staphylococcus aureus.
Journal of bacteriology - 1 Nov 2010
Geoghegan Joan A, Corrigan Rebecca M, Gruszka Dominika T, Speziale Pietro, O'Gara James P, Potts Jennifer R, Foster Timothy J
Abstract excerpt
The SasG surface protein of Staphylococcus aureus has been shown to promote the formation of biofilm. SasG comprises an N-terminal A domain and repeated B domains. Here we demonstrate that SasG is involved in the accumulation phase of biofilm, a process that requires a physiological concentration of Zn(2+). The B domains, but not the A domain, are required. Purified recombinant B domain protein can form dimers in...
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