MTHFR polymorphisms in relation to ovarian cancer risk.

doi:10.1016/j.ygyno.2010.08.007

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Article

MTHFR polymorphisms in relation to ovarian cancer risk.

Gynecologic oncology - 1 Nov 2010

Terry Kathryn L, Tworoger Shelley S, Goode Ellen L, Gates Margaret A, Titus-Ernstoff Linda, Kelemen Linda E, Sellers Thomas A, Hankinson Susan E, Cramer Daniel W

Abstract excerpt

OBJECTIVE: Folate has been hypothesized to influence carcinogenesis due to its dual role in DNA methylation, which regulates gene expression, and synthesis of purine and thymidylate, which is vital for DNA repair. Thus, we examined ovarian cancer risk in relation to two functional polymorphisms (C677T and A1298C) in the MTHFR gene. METHODS: We genotyped the C677T (rs1801133) and A1298C (rs1801131) MTHFR...

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Identifiers

PMID: 20817226
DOI: 10.1016/j.ygyno.2010.08.007
PMCID: PMC2952716

Genes

MTHFR
NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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