Article
Induction pegylated interferon alfa-2a and high dose ribavirin do not increase SVR in heavy patients with HCV genotype 1 and high viral loads.
Gastroenterology - 1 Dec 2010
Reddy K Rajender, Shiffman Mitchell L, Rodriguez-Torres Maribel, Cheinquer Hugo, Abdurakhmanov Djamal, Bakulin Igor, Morozov Viacheslav, Silva Giovanni Faria, Geyvandova Natalia, Stanciu Carol, Rabbia Michael, McKenna Michael, Thommes James A, Harrison Stephen A
Abstract excerpt
BACKGROUND & AIMS: Patients infected with hepatitis C virus (HCV) genotype 1, body weight ≥85 kg, and high baseline viral load respond poorly to standard doses of pegylated interferon (peginterferon) and ribavirin. We evaluated intensified therapy with peginterferon alfa-2a plus ribavirin. METHODS: This double-blind randomized trial included HCV genotype 1-infected outpatients from hepatology clinics with body...
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