Randomized clinical trial comparing high versus standard dose of ribavirin plus peginterferon alfa-2a in hepatitis C genotype 3 and high viral load. Dargen-3 study.

doi:10.1016/j.gastrohep.2013.10.005

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Randomized clinical trial comparing high versus standard dose of ribavirin plus peginterferon alfa-2a in hepatitis C genotype 3 and high viral load. Dargen-3 study.

Gastroenterologia y hepatologia - 1 Jan 2014

Fernández-Rodríguez Conrado M, Morillas Rosa María, Masnou Helena, Navarro José María, Bárcena Rafael, González José Manuel, Martín-Martín Leticia, Poyato Antonio, Miquel-Planas Mireia, Jorquera Francisco, Casanovas Teresa, Salmerón Javier, Calleja José Luis, Solà Ricard, Alonso Sonia, Planas Ramón, Romero-Gomez Manuel

Abstract excerpt

INTRODUCTION: Less than half of patients with chronic hepatitis C genotype 3 (G3) and high viral load (HVL) without a rapid virological response (RVR) achieve a sustained virological response (SVR) when treated with peginterferon plus ribavirin (RBV). OBJECTIVES: To assess the impact of high doses of RBV on SVR in patients with G3 and HVL. METHODS: Ninety-seven patients were randomized to receive peginterferon...

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PMID: 24360571
DOI: 10.1016/j.gastrohep.2013.10.005

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