Article
Viral hit and run-oncogenesis: genetic and epigenetic scenarios.
Cancer letters - 28 Jun 2011
Niller Hans Helmut, Wolf Hans, Minarovits Janos
Abstract excerpt
It is well documented that viral genomes either inserted into the cellular DNA or co-replicating with it in episomal form can be lost from neoplastic cells. Therefore, "hit and run"-mechanisms have been a topic of longstanding interest in tumor virology. The basic idea is that the transient acquisition of a complete or incomplete viral genome may be sufficient to induce malignant conversion of host cells in vivo,...
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