Article
An oligopeptide transporter of Mycobacterium tuberculosis regulates cytokine release and apoptosis of infected macrophages.
PloS one - 17 Aug 2010
Dasgupta Arunava, Sureka Kamakshi, Mitra Devrani, Saha Baisakhee, Sanyal Sourav, Das Amit K, Chakrabarti Parul, Jackson Mary, Gicquel Brigitte, Kundu Manikuntala, Basu Joyoti
Abstract excerpt
BACKGROUND: The Mycobacterium tuberculosis genome encodes two peptide transporters encoded by Rv3665c-Rv3662c and Rv1280c-Rv1283c. Both belong to the family of ABC transporters containing two nucleotide-binding subunits, two integral membrane proteins and one substrate-binding polypeptide. However, little is known about their functions in M. tuberculosis. Here we report functional characterization of the...
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