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Article

Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity.

The American journal of the medical sciences - 1 Oct 2010

Gloria-Bottini Fulvia, Saccucci Patrizia, Magrini Andrea, Bottini Egidio

Abstract excerpt

In this article, we confirm the positive association of acid phosphatase locus 1 (ACP1)*A/adenosine deaminase locus 1 (ADA1)*2 gametic type with type 1 diabetes (T1D) previously reported and show a negative correlation between the frequency of this gametic type with past malarial morbidity in Sardinia. One hundred seven adult women with T1D and 385 healthy adult women from the Caucasian population of Central...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20805743
DOI: 10.1097/MAJ.0b013e3181e62ae6

Genes

ACP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Is there a role of ACP1-ADA1 genetic complex in immune reaction? Association with T1D and with past malarial morbidity.PMID 20805743Read ↗

Type 1 diabetes: evidence of interaction between ACP1 and ADA1 gene polymorphisms.Semantic proximity Read ↗

Genetic factors adaptive in a malarial environment may increase the risk of type 1 diabetes.Semantic proximity Read ↗

A study of three polymorphic sites of the ADA gene in children with type 1 diabetes mellitus.Semantic proximity Read ↗

Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype.Semantic proximity Read ↗

Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: a study of adenosine deaminase and MN blood group genetic polymorphisms.Semantic proximity Read ↗

Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms.Semantic proximity Read ↗

Further observations on associations between the ADA gene and past malaria morbidity in Sardinia.Semantic proximity Read ↗

Association between the acid phosphatase 1 and adenosine deaminase systems in a Brazilian sample.Semantic proximity Read ↗

DNA methylation and mRNA expression of HLA-DQA1 alleles in type 1 diabetes mellitus.Semantic proximity Read ↗

ACP1 genetic polymorphism and coronary artery disease: an association study.Semantic proximity Read ↗

Association of the ACP1 genotype with metabolic parameters upon initial diagnosis of type 1 diabetes.Semantic proximity Read ↗

Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality.Semantic proximity Read ↗

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