Association between tumor necrosis factor-alpha (-308G→A and -238G→A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions.

Abstract excerpt

BACKGROUND AND PURPOSE: The aims of this study were to evaluate the role of tumor necrosis factor-α (TNF-α) polymorphisms in patients susceptible to ischemic stroke and silent brain infarction (SBI), and to determine the relationship between TNF-α polymorphisms and plasma total homocysteine (tHcy) levels. METHODS: We studied 237 patients with ischemic stroke, 257 patients with SBIs, and 216 control subjects. For...

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