Article
Evidence that polymorphic deletion of the glutathione S-transferase gene, GSTM1, is associated with esophageal atresia.
Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2010
Filonzi Laura, Magnani Cinzia, de' Angelis Gian Luigi, Dallaglio Sara, Nonnis Marzano Francesco
Abstract excerpt
BACKGROUND: Esophageal atresia (EA) is a life-threatening congenital condition whose etiology and pathogenesis are still poorly understood. An increasing trend of this pathology in some Italian regions suggests a possible interaction between xenobiotics and genes involved in detoxification processes during early embryonic development. For the first time polymorphisms of GSTM1, GSTT1, and GSTP1 genes were analyzed...
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