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Article

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia.

Neurobiology of disease - 1 Jan 2011

Tower Cristy, Fu Lianwu, Gill Rachel, Prichard Mark, Lesort Mathieu, Sztul Elizabeth

Abstract excerpt

The presence of aggregates of abnormally expanded polyglutamine (polyQ)-containing proteins are a pathological hallmark of a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxia-3 (SCA3). Previous studies in cellular, Drosophila, and mouse models of HD and SCA have shown that neurodegeneration can be prevented by manipulations that inhibit polyQ aggregation. We have...

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Identifiers

PMID: 20732421
DOI: 10.1016/j.nbd.2010.08.013
PMCID: PMC3771345

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PML
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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