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Article

The Set3/Hos2 histone deacetylase complex attenuates cAMP/PKA signaling to regulate morphogenesis and virulence of Candida albicans.

PLoS pathogens - 13 May 2010

Hnisz Denes, Majer Olivia, Frohner Ingrid E, Komnenovic Vukoslav, Kuchler Karl

Abstract excerpt

Candida albicans, like other pleiomorphic fungal pathogens, is able to undergo a reversible transition between single yeast-like cells and multicellular filaments. This morphogenetic process has long been considered as a key fungal virulence factor. Here, we identify the evolutionarily conserved Set3/Hos2 histone deacetylase complex (Set3C) as a crucial repressor of the yeast-to-filament transition. Cells lacking...

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Identifiers

PMID: 20485517
DOI: 10.1371/journal.ppat.1000889
PMCID: PMC2869326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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