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Article

The early natural history of bipolar disorder: what we have learned from longitudinal high-risk research.

Canadian journal of psychiatry. Revue canadienne de psychiatrie - 1 Aug 2010

Duffy Anne

Abstract excerpt

Longitudinal high-risk research has provided convergent evidence that major mood and psychotic disorders often develop from nonspecific antecedents in predisposed people over time and development. For example, bipolar disorder (BD) appears to evolve from nonspecific childhood antecedents, including anxiety and sleep problems, followed by adjustment and minor mood disturbances through early adolescence,...

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PMID: 20723275
DOI: 10.1177/070674371005500802

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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