Article
A new Ser472Asn (Cab2(a+)) polymorphism localized within the αIIb "thigh" domain is involved in neonatal thrombocytopenia.
Transfusion - 1 Feb 2011
Jallu Vincent, Dusseaux Mathilde, Kaplan Cecile
Abstract excerpt
BACKGROUND: A new platelet antigen, Cab2(a+), was identified in a case of severe neonatal alloimmune thrombocytopenia (<8 × 10(9)/L) in twins. STUDY DESIGN AND METHODS: Coding sequences of αIIb and β3 genes from parents were amplified and sequenced. CHO cell lines expressing wild-type or mutated forms of the complex were established to study the role of the mutation in alloimmunization and in αIIbβ3 functions....
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