Article
Polymorphisms of beta defensins are associated with the risk of severe acute pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2010
Tiszlavicz Z, Szabolcs A, Takács T, Farkas G, Kovács-Nagy R, Szántai E, Sasvári-Székely M, Mándi Y
Abstract excerpt
AIMS: Bacterial translocation from the intestinal tract plays an important role in severe acute pancreatitis (AP). Human β-defensins are a family of antimicrobial peptides present at the mucosal surface. The aim of this study was to investigate the relevance of single nucleotide polymorphisms (SNPs) in the DEFB1 gene and copy number polymorphisms of the DEFB4 genes in AP. METHODS: 124 AP patients (30 with mild...
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