Article
Prevalence of RhD variants, confirmed by molecular genotyping, in a multiethnic prenatal population.
American journal of clinical pathology - 1 Sept 2010
Wang Dehua, Lane Catherine, Quillen Karen
Abstract excerpt
RhD determination in pregnant women is critical to facilitate Rh immune globulin prophylaxis for RhD-negative women. A single amino acid change in the RhD antigen can cause epitope loss, giving rise to "partial D" variants. Women with some partial D variants may develop anti-D against the missing epitope after pregnancy. RBCs with partial D may type as D-positive or D-negative depending on the reagent used. We...
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