Article
Association study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder.
Behavioral and brain functions : BBF - 12 Aug 2010
Xu Xiaohui, Breen Gerome, Chen Chih-Ken, Huang Yu-Shu, Wu Yu-Yu, Asherson Philip
Abstract excerpt
BACKGROUND: The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidence implicate a relationship between attention-deficit hyperactivity disorder (ADHD), circadian rythmicity and sleeping disturbances. A recent study has reported that a polymorphism (rs1801260)...
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