Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification.

Clinical chemistry - 1 Oct 2010

Awan Zuhier, Alwaili Khalid, Alshahrani Ali, Langsetmo Lisa, Goltzman David, Genest Jacques

Abstract excerpt

BACKGROUND: Familial hypercholesterolemia (FH) due to mutations in the low-density lipoprotein receptor (LDLR) gene exhibit severe, premature aortic calcification in a gene-dosage, age-dependent fashion. We sought to determine potential associations with mineral and skeletal indices. METHODS: We obtained computed tomography (CT) scan aortic calcium scores (AoCSs) in 19 (age 49 [SD 14] years) FH patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Diseases
Share to Bone and Bones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcinosis

Share to Hyperlipoproteinemia Type II

Share to Hypolipidemic Agents

Share to Lipoproteins, LDL

Share to Osteocalcin

Share to Receptors, LDL

Source

Identifiers

PMID: 20702785
DOI: 10.1373/clinchem.2010.147066

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification.PMID 20702785Read ↗

Vascular calcifications in homozygote familial hypercholesterolemia.Semantic proximity Read ↗

Increased Aortic Valve Calcification in Familial Hypercholesterolemia: Prevalence, Extent, and Associated Risk Factors.Semantic proximity Read ↗

Genetic determinants of arterial calcification associated with atherosclerosis.Semantic proximity Read ↗

Assessment of Subclinical Atherosclerosis Using Computed Tomography Calcium Scores in Patients with Familial and Nonfamilial Hypercholesterolemia.Semantic proximity Read ↗

CT coronary plaque burden in asymptomatic patients with familial hypercholesterolaemia.Semantic proximity Read ↗

Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice.Semantic proximity Read ↗

Parathyroid hormone gene variant and calcific aortic stenosis.Semantic proximity Read ↗

The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis.Semantic proximity Read ↗

Coronary calcium: the good, the bad, and the uncertain.Semantic proximity Read ↗

CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events.Semantic proximity Read ↗

Lifetime, untreated isolated GH deficiency due to a GH-releasing hormone receptor mutation has beneficial consequences on bone status in older individuals, and does not influence their abdominal aorta calcification.Semantic proximity Read ↗

Coronary Artery Calcification and Rheumatoid Arthritis: Lack of Relationship to Risk Alleles for Coronary Artery Disease in the General Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.