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Article

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.

The Journal of clinical investigation - 1 Sept 2010

Molyneux Sam D, Di Grappa Marco A, Beristain Alexander G, McKee Trevor D, Wai Daniel H, Paderova Jana, Kashyap Meenakshi, Hu Pingzhao, Maiuri Tamara, Narala Swami R, Stambolic Vuk, Squire Jeremy, Penninger Josef, Sanchez Otto, Triche Timothy J, Wood Geoffrey A, Kirschner Lawrence S, Khokha Rama

Abstract excerpt

Some cancers have been stratified into subclasses based on their unique involvement of specific signaling pathways. The mapping of human cancer genomes is revealing a vast number of somatic alterations; however, the identification of clinically relevant molecular tumor subclasses and their respec...

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Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Source

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Identifiers

PMID: 20697156
DOI: 10.1172/JCI42391
PMCID: PMC2929719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20697156-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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