Article
The molecular characterization of a novel GH38 α-mannosidase from the crenarchaeon Sulfolobus solfataricus revealed its ability in de-mannosylating glycoproteins.
Biochimie - 1 Dec 2010
Cobucci-Ponzano Beatrice, Conte Fiorella, Strazzulli Andrea, Capasso Clemente, Fiume Immacolata, Pocsfalvi Gabriella, Rossi Mosè, Moracci Marco
Abstract excerpt
α-Mannosidases, important enzymes in the N-glycan processing and degradation in Eukaryotes, are frequently found in the genome of Bacteria and Archaea in which their function is still largely unknown. The α-mannosidase from the hyperthermophilic Crenarchaeon Sulfolobus solfataricus has been identified and purified from cellular extracts and its gene has been cloned and expressed in Escherichia coli. The gene,...
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