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Article

Multiplex analysis of age-related protein and lipid modifications in human Bruch's membrane

5 Aug 2010

Abstract excerpt

Aging of the human retina is characterized by progressive pathology, which can lead to vision loss. This progression is believed to involve reactive metabolic intermediates reacting with constituents of Bruch's membrane, significantly altering its physiochemical nature and function. We aimed to replace a myriad of techniques following these changes with one, Raman spectroscopy. We used multiplexed Raman...

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PMID: 20686107
DOI: 10.1096/fj.10-166090

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