Article
Genomic characterization of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients.
Leukemia research - 1 Apr 2011
Joha Sami, Dauphin Véronique, Leprêtre Frédéric, Corm Sélim, Nicolini Franck E, Roumier Christophe, Nibourel Olivier, Grardel Nathalie, Maguer-Satta Véronique, Idziorek Thierry, Figeac Martin, Laï Jean-Luc, Quesnel Bruno, Etienne Gabriel, Guilhot François, Lippert Eric, Preudhomme Claude, Roche-Lestienne Catherine
Abstract excerpt
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34(+) cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients' T-cells as reference, we found significant association between number of acquired cryptic copy number alterations (CNA) and disease phase (p=0.036) or loss of IM response for...
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