Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2010

Bhattacharyya Sanjib, Bhattacharya Resham, Curley Steven, McNiven Mark A, Mukherjee Priyabrata

Abstract excerpt

Treatment with monoclonal antibody (mAbs) is a viable therapeutic option in cancer. Recently, these mAbs such as cetuximab, herceptin, etc., have been used as targeting agents to selectively deliver chemotherapeutics to cancerous cells. However, mechanisms of nanoparticles-mAbs interactions with the target cells and its effect on intracellular trafficking and mechanism are currently unknown. In this paper, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gold
Share to Endosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibodies, Monoclonal, Humanized

Share to Carbocyanines

Share to Cetuximab

Share to Dynamin II

Share to Golgi Apparatus

Share to Metal Nanoparticles

Source

Open in PubMed Open full text

Identifiers

PMID: 20679244
DOI: 10.1073/pnas.1006507107
PMCID: PMC2930461

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis.PMID 20679244Read ↗

Multiparatopic antibodies overcome tyrosine kinase inhibitor resistance by inducing lysosomal degradation of EGFR mutants.Semantic proximity Read ↗

Direct Observation of Endocytosis Dynamics of Anti-ErbB Modified Single NanocargoesSemantic proximity Read ↗

Multiparatopic antibodies overcome tyrosine kinase inhibitor resistance by inducing lysosomal degradation of EGFR mutantsSemantic proximity Read ↗

Targeted Protein Degradation via NanoparticlesSemantic proximity Read ↗

Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery.Semantic proximity Read ↗

Enhanced Efficacy of EGFR-Targeted ADCs via p38-Mediated Noncanonical Endocytosis in EGFR-Mutant Lung Cancer Cells.Semantic proximity Read ↗

Enhanced HER2 internalization by clathrin-dependent endocytosis in non-small cell lung cancer positive for HER2 mutations.Semantic proximity Read ↗

Enhancing Cancer Therapy through Polymeric Nano-particles: Targeted Drug Delivery StrategiesSemantic proximity Read ↗

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers.Semantic proximity Read ↗

Intracellular KRAS-specific antibody enhances the anti-tumor efficacy of gemcitabine in pancreatic cancer by inducing endosomal escape.Semantic proximity Read ↗

Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer.Semantic proximity Read ↗

Exosomes containing miRNAs targeting HER2 synthesis and engineered to adhere to HER2 on tumor cells surface exhibit enhanced antitumor activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.