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Article

Attenuation of bacterial virulence by quorum sensing-regulated lysis.

Journal of biotechnology - 1 Oct 2010

Silva Anisia J, Benitez Jorge A, Wu Jian-He

Abstract excerpt

Genetically attenuated pathogenic bacteria have been extensively considered as vaccine candidates. However, insufficient attenuation has been a frequent limitation of this approach. Many pathogens use quorum sensing to escape host defense mechanism. Here, we hypothesized that quorum sensing can be manipulated to diminish pathogenesis. To test this hypothesis, we modified the quorum sensing circuitry of a live...

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Identifiers

PMID: 20673838
DOI: 10.1016/j.jbiotec.2010.07.025
PMCID: PMC2974442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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