Article
Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells.
International journal of oncology - 1 Sept 2010
Monzavi-Karbassi Behjatolah, Hine R Jean, Stanley Joseph S, Ramani Vishnu Prakash, Carcel-Trullols Jaime, Whitehead Tracy L, Kelly Thomas, Siegel Eric R, Artaud Cecile, Shaaf Saeid, Saha Rinku, Jousheghany Fariba, Henry-Tillman Ronda, Kieber-Emmons Thomas
Abstract excerpt
Aberrant glycosylation is a universal feature of cancer cells, and certain glycan structures are well-known markers for tumor progression. Availability and composition of sugars in the microenvironment may affect cell glycosylation. Recent studies of human breast tumor cell lines indicate their ability to take up and utilize fructose. Here we tested the hypothesis that adding fructose to culture as a carbon...
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