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The Viral Replication Complex Is Associated with the Virulence of Newcastle Disease Virus

22 Jul 2010

Abstract excerpt

Virulent strains of Newcastle disease virus ([NDV] also known as avian paramyxovirus type 1) can be discriminated from low-virulence strains by the presence of multiple basic amino acid residues at the proteolytic cleavage site of the fusion (F) protein. However, some NDV variants isolated from pigeons (pigeon paramyxovirus type 1 [PPMV-1]) have low levels of virulence, despite the fact that their F protein...

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PMID: 20660202
DOI: 10.1128/jvi.00097-10

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