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Article

Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia.

PLoS neglected tropical diseases - 20 Jul 2010

Vu Thi Ty Hang, Holmes Edward C, Duong Veasna, Nguyen Thien Quy, Tran Tinh Hien, Quail Michael, Churcher Carol, Parkhill Julian, Cardosa Jane, Farrar Jeremy, Wills Bridget, Lennon Niall J, Birren Bruce W, Buchy Philippe, Henn Matthew R, Simmons Cameron P

Abstract excerpt

A better description of the extent and structure of genetic diversity in dengue virus (DENV) in endemic settings is central to its eventual control. To this end we determined the complete coding region sequence of 187 DENV-2 genomes and 68 E genes from viruses sampled from Vietnamese patients between 1995 and 2009. Strikingly, an episode of genotype replacement was observed, with Asian 1 lineage viruses entirely...

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Identifiers

PMID: 20651932
DOI: 10.1371/journal.pntd.0000757
PMCID: PMC2907417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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