Article
The ethnospecific distribution of the HFE haplotypes for IVS2(+4)t/c, IVS4(-44)t/c, and IVS5(-47)g/a in populations of Russia and possible effects of these single-nucleotide polymorphisms in splicing.
Genetic testing and molecular biomarkers - 1 Aug 2010
Mikhailova Svetlana Vladimirovna, Babenko Vladimir Nikolaevich, Voevoda Mikhail Ivanovich, Romashchenko Aida Gerasimovna
Abstract excerpt
AIM: The aim of this work was a haplotype analysis of the major mutations (C282Y, H63D, S65C) and IVS2(+4)t/c, IVS4(-44)t/c, and IVS5(-47)a/g polymorphisms of the hemochromatosis HFE gene in populations inhabiting the territories of Russia (Russians, Finno-Ugrians, Central Asians, and Arctic Mongoloids). METHOD: The hemochromatosis gene (HFE) alleles were detected using the polymerase chain reaction/restriction...
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