Article
Functional roles for the GerE-family carboxyl-terminal domains of nitrate response regulators NarL and NarP of Escherichia coli K-12.
Microbiology (Reading, England) - 1 Oct 2010
Lin Alice V, Stewart Valley
Abstract excerpt
NarL and NarP are paralogous response regulators that control anaerobic gene expression in response to the favoured electron acceptors nitrate and nitrite. Their DNA-binding carboxyl termini are in the widespread GerE-LuxR-FixJ subfamily of tetrahelical helix-turn-helix domains. Previous biochemical and crystallographic studies with NarL suggest that dimerization and DNA binding by the carboxyl-terminal domain...
Topics
- Amino Acid Sequence
- Amino Acid Substitution
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation