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Article

Mutational analysis reveals functional similarity between NARX, a nitrate sensor in Escherichia coli K-12, and the methyl-accepting chemotaxis proteins.

Journal of bacteriology - 1 Jun 1992

Collins L A, Egan S M, Stewart V

Abstract excerpt

During anaerobic growth, nitrate induces synthesis of the anaerobic respiratory enzymes formate dehydrogenase-N and nitrate reductase. This induction is mediated by a transcription activator, the narL gene product. The narX gene product may be involved in sensing nitrate and phosphorylating NARL. We isolated narX mutants, designated narX*, that caused nitrate-independent expression of the formate dehydrogenase-N...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
DNA Mutational Analysis
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genetic Complementation Test
Membrane Proteins
Methyl-Accepting Chemotaxis Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Molybdenum

Mutagenesis

Mutation

Nitrates

Phenotype

Protein Kinases

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 1592821
DOI: 10.1128/jb.174.11.3667-3675.1992
PMCID: PMC206056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1592821-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutational analysis reveals functional similarity between NARX, a nitrate sensor in Escherichia coli K-12, and the methyl-accepting chemotaxis proteins.PMID 1592821Read ↗

Nitrate- and nitrite-sensing protein NarX of Escherichia coli K-12: mutational analysis of the amino-terminal tail and first transmembrane segment.Semantic proximity Read ↗

Nitrate- and molybdenum-independent signal transduction mutations in narX that alter regulation of anaerobic respiratory genes in Escherichia coli.Semantic proximity Read ↗

Nitrate regulation of anaerobic respiratory gene expression in narX deletion mutants of Escherichia coli K-12.Semantic proximity Read ↗

Discrimination between structurally related ligands nitrate and nitrite controls autokinase activity of the NarX transmembrane signal transducer of Escherichia coli K-12.Semantic proximity Read ↗

Role of the periplasmic domain of the Escherichia coli NarX sensor-transmitter protein in nitrate-dependent signal transduction and gene regulation.Semantic proximity Read ↗

Functional roles for the GerE-family carboxyl-terminal domains of nitrate response regulators NarL and NarP of Escherichia coli K-12.Semantic proximity Read ↗

Asymmetric cross-regulation between the nitrate-responsive NarX-NarL and NarQ-NarP two-component regulatory systems from Escherichia coli K-12.Semantic proximity Read ↗

Identification and characterization of narQ, a second nitrate sensor for nitrate-dependent gene regulation in Escherichia coli.Semantic proximity Read ↗

Mutational analysis of nitrate regulatory gene narL in Escherichia coli K-12.Semantic proximity Read ↗

Genetic evidence that NarL function is not required for nitrate regulation of nitrate assimilation in Klebsiella pneumoniae M5al.Semantic proximity Read ↗

A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth.Semantic proximity Read ↗

Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1.Semantic proximity Read ↗

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