Article
RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.
Autism research : official journal of the International Society for Autism Research - 1 Aug 2010
Huang Hsien-Sung, Cheung Iris, Akbarian Schahram
Abstract excerpt
Dysfunction of cerebral cortex in autism is thought to involve alterations in inhibitory neurotransmission. Here, we screened, in prefrontal cortex (PFC) of 15 subjects diagnosed with autism and 15 matched controls the expression of 44 transcripts that are either preferentially expressed in gamma-aminobutyric acidergic interneurons of the mature cortex or important for the development of inhibitory circuitry....
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