Article
Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991
Hall B G
Abstract excerpt
A previous study has demonstrated that adaptive missense mutations occur in the trp operon of Escherichia coli. In this study it is shown that, under conditions of intense selection, a strain carrying missense mutations in both trpA and trpB reverts to Trp+ 10(8) times more frequently than would be expected if the two mutations were the result of independent events. Comparison of the single mutation rates with...
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