Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions.

doi:10.1073/pnas.88.13.5882

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Article

Adaptive evolution that requires multiple spontaneous mutations: mutations involving base substitutions.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1991

Hall B G

Abstract excerpt

A previous study has demonstrated that adaptive missense mutations occur in the trp operon of Escherichia coli. In this study it is shown that, under conditions of intense selection, a strain carrying missense mutations in both trpA and trpB reverts to Trp+ 10(8) times more frequently than would...

Topics

Biological Evolution
DNA, Bacterial
Escherichia coli
Genes, Bacterial
Mutation
Operon
Polymerase Chain Reaction
Tryptophan

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