Article
Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency.
Clinical immunology (Orlando, Fla.) - 1 Sept 2010
Freiberger T, Grodecká L, Ravcuková B, Kurecová B, Postránecká V, Vlcek J, Jarkovský J, Thon V, Litzman J
Abstract excerpt
The neonatal Fc receptor (FcRn) acts as a key regulator of IgG homeostasis and is an important sensor of luminal infection. We analyzed the influence of FcRn expression on disease phenotype and the catabolism of therapeutically administered intravenous immunoglobulins (IVIG) in 28 patients with common variable immunodeficiency (CVID). Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN...
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